CDR State Transition Probabilities in Alzheimer's Disease with and without
Cholinesterase Inhibitor Intervention in an Observational Cohort of AD Patients
 
   Lead Investigator:    Lisa Bloudek
   Institution      :    University of Washington
   E-Mail           :    mandin@u.washington.edu
   Proposal ID      :    98



   Proposal Description:
   Specific Aim 1: My first aim is to attempt to control for confounding by  indication in the association between cholinesterase inhibitors and the  probability of transitioning to more severe CDR states. I will do this by  identifying AD patients in the NACC-UDS database who did not report use of  cholinesterase inhibitors at baseline enrollment, but do report use of  cholinesterase inhibitors at any time during subsequent data collection points  to serve as an observational cohort of AD patients who are started on treatment  before the disease progresses. These patients will be compared to patients who  never report use of cholinesterase inhibitors    Specific Aim 2: My second aim is to model AD progression with and without  treatment with cholinesterase inhibitors by modifying the recent model with  differentiation of treated versus untreated group to produce transition  probabilities for moving to more severe CDR states and the probability of  transitioning to institutionalization.